I build repair and service windows based desktops,laptops. Been doing this for over twenty years now and always more to learn...ever changing technology... as is life itself!
Best I can advise to make sure all software is updated. If you have XP get sp3 or latest Service Packs that apply to your OS. After that I if your usb mouse is wireless like mine ....new batery and locate transmitter closer to mouse. If all still fails buy a new mouse.. Good luck!