First of all, RAID 0+1 generally means using four hard drives, but it's always an even number. Two for the original striped array, and two more for backup for example.That's a considerable increase in noise, while you're still at the disk capacity of one hard drive, and even close to twice the noise one hard disk creates. It's an increase of 9 dB, regardless of what hard drives are used, and a 10 dB increase counts as twice as loud for our ears (even though it's a factor 10 increase in noise power level, as it's a logarithmic scale). You'll notice the difference
Second, it's complete overkill for most, you have to ask youself: Do I really need all that speed, and am I willing to pay the price for it as well?
RAID 0 on its own makes it twice as likely that you lose the data on those harddisks, adding RAID 1 lowers the odds somewhat, but because of using four harddisks in total, it's still possible. So there is also a higher cost for maintaining the RAID set-up.